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    Znrf3 zinc and ring finger 3 [ Mus musculus (house mouse) ]

    Gene ID: 407821, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Znrf3provided by MGI
    Official Full Name
    zinc and ring finger 3provided by MGI
    Primary source
    MGI:MGI:3039616
    See related
    Ensembl:ENSMUSG00000041961 AllianceGenome:MGI:3039616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1167
    Summary
    Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Involved in regulation of Wnt signaling pathway and stem cell proliferation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in vibrissa. Orthologous to human ZNRF3 (zinc and ring finger 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 4.8), thymus adult (RPKM 4.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A1; 11 3.46 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5226329..5394847, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5276329..5444847, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene kringle containing transmembrane protein 1 Neighboring gene predicted gene, 46268 Neighboring gene predicted gene, 30172 Neighboring gene STARR-seq mESC enhancer starr_28426 Neighboring gene STARR-seq mESC enhancer starr_28427 Neighboring gene STARR-positive B cell enhancer ABC_E8384 Neighboring gene STARR-seq mESC enhancer starr_28430 Neighboring gene STARR-seq mESC enhancer starr_28431 Neighboring gene STARR-seq mESC enhancer starr_28432 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5400351-5400552 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5401062-5401263 Neighboring gene STARR-seq mESC enhancer starr_28434 Neighboring gene predicted gene 11963 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide D pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9357 Neighboring gene X-box binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZNRF3 Regulates Collagen-Induced Arthritis Through NF-kB and Wnt Pathways. Liang JJ, et al. Inflammation, 2020 Jun. PMID 32125593
    2. Sexually dimorphic activation of innate antitumor immunity prevents adrenocortical carcinoma development. Wilmouth JJ Jr, et al. Sci Adv, 2022 Oct 14. PMID 36240276, Free PMC Article
    3. ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation. Sun T, et al. Cell Stem Cell, 2021 Oct 7. PMID 34129813
    4. RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis. Lu C, et al. Stem Cell Reports, 2022 Feb 8. PMID 34995498, Free PMC Article
    5. Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3. Zebisch M, et al. J Struct Biol, 2015 Aug. PMID 26123262, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.
      Title: RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.
    2. ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation.
      Title: ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation.
    3. ZNRF3 Regulates Collagen-Induced Arthritis Through NF-kB and Wnt Pathways.
      Title: ZNRF3 Regulates Collagen-Induced Arthritis Through NF-kB and Wnt Pathways.
    4. adrenocortical-specific loss of ZNRF3, but not RNF43, results in adrenal hyperplasia that depends on Porcupine-mediated Wnt ligand secretion.
      Title: A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis.
    5. XY mice lacking ZNRF3 exhibit complete or partial gonadal sex reversal, or related defects.
      Title: ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.
    6. RSPO-LGR4/5-ZNRF3/RNF43 module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.
      Title: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.
    7. Crystal structure confirming that Rspo proteins cross-link LGRs and ZNRF3 into a 2:2:2 complex.
      Title: Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.
    8. ZNRF3 binds RSPO1 and LGR5-RSPO1 with micromolar affinity via RSPO1 furin-like 1 (Fu1) domain.
      Title: Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling.
    9. data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3
      Title: ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables frizzled binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt receptor catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Wnt receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of non-canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Wnt signaling pathway, planar cell polarity pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase ZNRF3
    Names
    RING-type E3 ubiquitin transferase ZNRF3
    zinc/RING finger protein 3
    NP_001074393.1
    NP_001277430.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080924.2 → NP_001074393.1  E3 ubiquitin-protein ligase ZNRF3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001074393.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL662853, AL662876
      Consensus CDS
      CCDS36102.1
      UniProtKB/Swiss-Prot
      B2RXA5, Q3V095, Q5SSZ7
      Related
      ENSMUSP00000105493.2, ENSMUST00000109867.8
      Conserved Domains (1) summary
      pfam13639
      Location:289 → 331
      zf-RING_2; Ring finger domain

    2. NM_001290501.1 → NP_001277430.1  E3 ubiquitin-protein ligase ZNRF3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding sequence, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK133342, AL662853
      Consensus CDS
      CCDS70134.1
      UniProtKB/Swiss-Prot
      Q5SSZ7
      Related
      ENSMUSP00000134698.2, ENSMUST00000172492.8
      Conserved Domains (1) summary
      pfam13639
      Location:193 → 235
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      5226329..5394847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SSZ7.1 GenPept UniProtKB/Swiss-Prot:Q5SSZ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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